cholesterol transport

By Targets:	Autophagy (1) Biochemical Assay Reagents (2) Dengue virus (1) Flavivirus (1) Fluorescent Dye (1) HCV (1) Ligands for Target Protein for PROTAC (1) LXR (2)
By Research Areas:	Cancer (1) Infection (1) Inflammation/Immunology (1) Metabolic Disease (1) Neurological Disease (2)

Targets Recommended: FATP Acyltransferase

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-150407

TSPO ligand-1	Ligands for Target Protein for PROTAC Autophagy	Others Neurological Disease Cancer
TSPO ligand-1 is the ligand of AUTAC4 (HY-134640) that can be used in the synthesis of PROTACs. TSPO ligand-1 is a mitochondrial outer membrane transmembrane structural domain protein can bind to AUTAC4 and regulate mitochondrial autophagy to promote targeted mitochondrial renewal. TSPO ligand-1 is also involved in the transport of cholesterol from the outer to inner mitochondrial membrane and serves as a sensitive biomarker of brain injury and neurodegeneration .

HY-107433

U18666A 10+ Cited Publications	Flavivirus Dengue virus HCV	Infection Neurological Disease
U18666A, an intra-cellular **cholesterol transport** inhibitor, inhibits replication of Ebola virus, dengue virus, and human hepatitis C virus .

HY-154928

GW6340

LXR Metabolic Disease

GW6340 is an intestinal-specific LXR agonist. GW6340 promotes macrophage reverse cholesterol transport (mRCT) .

GW6340	LXR	Metabolic Disease
GW6340 is an intestinal-specific LXR agonist. GW6340 promotes macrophage reverse cholesterol transport (mRCT) .

HY-D1595

BODIPY FL Cholesterol	Fluorescent Dye	Others
BODIPY FL Cholesterol is a green fluorescent, lipophilic probe. BODIPY FL Cholesterol can be used for the research of lipid transport processes and lipid-protein interactions .

HY-118667

Dehydroergosterol Ergosta-5,7,9(11),22-tetraen-3β-ol	Biochemical Assay Reagents	Others
Dehydroergosterolis a naturally occurring fluorescent sterol analog (Ex/Em=325/375 nm), which mimics the properties of cholesterol in cell membranes. DehydroergosterolEasily conjugated by cholesterol-binding proteins for real-time imaging in live cells. DehydroergosterolThe sterol environment and intracellular sterol transport in vivo can be probed/elucidated in real time .

HY-133971

Cholesterol 5α,6α-epoxide 5α,6α-Epoxycholesterol	Biochemical Assay Reagents	Others
Cholesterol-5α,6α-epoxide is an epoxide derivative of cholesterol formed by the enzymatic oxidation of cholesterol in the liver and other tissues. Cholesterol-5α,6α-epoxide has unique chemical properties that make it an important intermediate in the biosynthesis of bile acids, which play a key role in the digestion and absorption of dietary fats. It also has a potential physiological role in regulating cholesterol metabolism and transport, although its biological function is not fully understood.

HY-123148

IMB-808	LXR	Inflammation/Immunology
IMB-808 is a potent LXRα/β dual agonist with EC₅₀ values of 0.53 μM and 0.15 μM (0.15 μM, using GAL4-pGL4-luc reporter plasmid) for LXRβ and LXRα, respectively. IMB-808 promotes expression of genes related to reverse cholesterol transport (ABCA1 and ABCG1). IMB-808 can be used as a promising agent for the prospective treatment of atherosclerosis research .

Cat. No.	Product Name	Type

HY-D1595

BODIPY FL Cholesterol	Fluorescent Dyes/Probes
BODIPY FL Cholesterol is a green fluorescent, lipophilic probe. BODIPY FL Cholesterol can be used for the research of lipid transport processes and lipid-protein interactions .

Cat. No.	Product Name	Type

HY-133971

Cholesterol 5α,6α-epoxide 5α,6α-Epoxycholesterol	Biochemical Assay Reagents
Cholesterol-5α,6α-epoxide is an epoxide derivative of cholesterol formed by the enzymatic oxidation of cholesterol in the liver and other tissues. Cholesterol-5α,6α-epoxide has unique chemical properties that make it an important intermediate in the biosynthesis of bile acids, which play a key role in the digestion and absorption of dietary fats. It also has a potential physiological role in regulating cholesterol metabolism and transport, although its biological function is not fully understood.

Cholesterol 5α,6α-epoxide

5α,6α-Epoxycholesterol

Biochemical Assay Reagents

Cholesterol-5α,6α-epoxide is an epoxide derivative of cholesterol formed by the enzymatic oxidation of cholesterol in the liver and other tissues. Cholesterol-5α,6α-epoxide has unique chemical properties that make it an important intermediate in the biosynthesis of bile acids, which play a key role in the digestion and absorption of dietary fats. It also has a potential physiological role in regulating cholesterol metabolism and transport, although its biological function is not fully understood.

HY-118667

Dehydroergosterol Ergosta-5,7,9(11),22-tetraen-3β-ol	Biochemical Assay Reagents
Dehydroergosterolis a naturally occurring fluorescent sterol analog (Ex/Em=325/375 nm), which mimics the properties of cholesterol in cell membranes. DehydroergosterolEasily conjugated by cholesterol-binding proteins for real-time imaging in live cells. DehydroergosterolThe sterol environment and intracellular sterol transport in vivo can be probed/elucidated in real time .

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Inhibitors & Agonists

Fluorescent Dye

Biochemical Assay Reagents